Tsuruda J, James H E, Werner R, Camp P E, Rasmussen G
Acta Neurochir (Wien). 1983;69(1-2):77-91. doi: 10.1007/BF02055856.
Albino rabbits with experimental brain oedema produced by a combined left hemisphere cryogenic injury and a metabolic insult by a 6-aminonicotinamide (6-ANA) were administered intravenous dimethyl sulphoxide (DMSO) in varying concentrations and doses in the following manner: Subgroup A (concentration response) received 1.0 g/kg bolus of a 10, 20, 30, or 40% solution. Subgroup B (dose response) received as a 20% solution a 1.0 g/kg bolus, 1.5 g/kg bolus, or 2.0 g/kg infusion. One hour following administration of the agent, the animals were killed, their brains rapidly removed by craniectomy and brain water, sodium and potassium measured. Significant decreases in brain sodium and water content in the right hemisphere were noted in both subgroups A (p less than 0.05) and B (p less than 0.005) and in the left hemisphere in subgroup B only (p less than 0.005). There is an apparent effect on brain oedema by a DMSO mediated sodium dependent water mobilization.
对通过左半球低温损伤联合6-氨基烟酰胺（6-ANA）代谢损伤产生实验性脑水肿的白化兔，以以下方式静脉注射不同浓度和剂量的二甲基亚砜（DMSO）：A组（浓度反应）接受1.0 g/kg推注的10%、20%、30%或40%溶液。B组（剂量反应）接受作为20%溶液的1.0 g/kg推注、1.5 g/kg推注或2.0 g/kg输注。给药1小时后，处死动物，通过颅骨切除术迅速取出其大脑，并测量脑含水量、钠含量和钾含量。A组（p<0.05）和B组（p<0.005）右半球以及仅B组左半球（p<0.005）的脑钠含量和含水量均显著降低。DMSO介导的钠依赖性水动员对脑水肿有明显影响。
