地塞米松在体内对大鼠睾丸中参与丙酮酸-苹果酸途径的脂肪生成酶的直接影响。

Direct influence of dexamethasone in vivo on rat testicular lipogenic enzymes involved in pyruvate-malate pathway.

作者信息

Valivullah H M, Aruldhas M M, Govindarajulu P

出版信息

Biochem Biophys Res Commun. 1983 Sep 15;115(2):606-10. doi: 10.1016/s0006-291x(83)80187-9.

Abstract

The changes in specific activities of NADP-isocitrate dehydrogenase, ATP-citrate lyase, Malate dehydrogenase and malic enzyme were studied in adrenalectomised and dexamethasone injected pubertal rats. One month after adrenalectomy the specific activity of NADP-isocitrate dehydrogenase increased but the specific activities of the other three enzymes decreased. An opposite effect was seen after dexamethasone administration to intact animals. The changes observed in the specific activities of enzymes of adrenalectomised and dexamethasone treated animals reverted back to normal after dexamethasone replacement and withdrawal, respectively.

摘要

研究了肾上腺切除及注射地塞米松的青春期大鼠中烟酰胺腺嘌呤二核苷酸磷酸异柠檬酸脱氢酶、ATP柠檬酸裂解酶、苹果酸脱氢酶和苹果酸酶的比活性变化。肾上腺切除术后1个月，烟酰胺腺嘌呤二核苷酸磷酸异柠檬酸脱氢酶的比活性增加，但其他三种酶的比活性降低。对未切除肾上腺的动物给予地塞米松后观察到相反的效果。肾上腺切除和地塞米松处理动物的酶比活性变化分别在给予地塞米松替代物和停药后恢复正常。