甲状腺切除术对参与脂肪生成的丙酮酸/苹果酸循环中睾丸酶的影响。
Effect of thyroidectomy on testicular enzymes of the pyruvate/malate cycle involved in lipogenesis.
作者信息
Aruldhas M M, Valivullah H M, Govindarajulu P
出版信息
Biochim Biophys Acta. 1983 Jan 4;755(1):90-4. doi: 10.1016/0304-4165(83)90277-5.
The specific activities of testicular enzymes of the pyruvate/malate cycle involved in lipogenesis after thyroidectomy and thyroxine replacement were studied in prepubertal, pubertal and adult rats. Thyroidectomy induced testicular ATP citrate-lyase, malate dehydrogenase and malic enzyme activities and inhibited isocitrate dehydrogenase (NADP+) activity. Thyroxine treatment on thyroidectomized animals reverted all enzyme activities to normal. The result suggests that thyroid hormones have a differential effect on testicular enzymes of the pyruvate/malate cycle involved in lipogenesis.
在青春期前、青春期和成年大鼠中，研究了甲状腺切除术后和甲状腺素替代后参与脂肪生成的丙酮酸/苹果酸循环中睾丸酶的比活性。甲状腺切除诱导了睾丸ATP柠檬酸裂解酶、苹果酸脱氢酶和苹果酸酶活性，并抑制了异柠檬酸脱氢酶（NADP+）活性。对甲状腺切除动物进行甲状腺素治疗可使所有酶活性恢复正常。结果表明，甲状腺激素对参与脂肪生成的丙酮酸/苹果酸循环中的睾丸酶有不同的影响。
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