甲状腺素诱导的甲状腺功能亢进对丙酮酸/苹果酸循环中某些睾丸酶的影响。
Effect of thyroxine-induced hyperthyroidism on some testicular enzymes of the pyruvate/malate cycle.
作者信息
Aruldhas M M, Valivullah H M, Govindarajulu P
出版信息
Biochim Biophys Acta. 1984 Feb 14;797(2):143-6. doi: 10.1016/0304-4165(84)90115-6.
The effect of thyroxine on the specific activities of testicular enzymes of the pyruvate/malate cycle involved in lipogenesis were studied in prepubertal, pubertal and adult rats. Thyroxine (25 micrograms/100 g body weight) treatment for 1 month increased the specific activity of isocitrate dehydrogenase (NADP+) but the specific activities of ATP-citrate lyase, malate dehydrogenase and malic enzyme were inhibited. Withdrawal of thyroxine treatment from hyperthyroid rats brought back all enzyme activities to normal. The study reveals a direct, specific influence of thyroxine on different testicular enzymes of the pyruvate/malate cycle.
在青春期前、青春期和成年大鼠中，研究了甲状腺素对参与脂肪生成的丙酮酸/苹果酸循环中睾丸酶比活性的影响。用甲状腺素（25微克/100克体重）处理1个月可增加异柠檬酸脱氢酶（NADP+）的比活性，但ATP-柠檬酸裂解酶、苹果酸脱氢酶和苹果酸酶的比活性受到抑制。从甲状腺功能亢进的大鼠中撤去甲状腺素治疗后，所有酶活性恢复正常。该研究揭示了甲状腺素对丙酮酸/苹果酸循环中不同睾丸酶的直接、特异性影响。
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