Grandjean P, Thomsen G
Br J Ind Med. 1983 Nov;40(4):456-61. doi: 10.1136/oem.40.4.456.
At two x ray examinations in 1957 and 1967, 17 cases of skeletal fluorosis were identified among long term cryolite workers in Copenhagen. In 1982 four of these patients were alive, eight to 15 years after exposure had ended. Radiographs were obtained, and the urinary fluoride excretion was measured. A similar picture emerged in all four cases: extensive fading of the sclerosis of trabecular bone in ribs, vertebral bodies, and pelvis, whereas cortical bone thickening and calcification of muscle insertions and ligaments remained virtually unchanged. The fluoride excretion was increased in three cases (with the shortest exposure free period). These findings indicate that with continuous remodelling of bone tissue trabecular sclerosis is slowly reversible and the excess fluoride is excreted in the urine.
在1957年和1967年的两次X线检查中，哥本哈根的长期冰晶石工人中确诊了17例骨氟中毒病例。1982年，这些患者中有4人存活，此时距离接触结束已有8至15年。拍摄了X光片，并测量了尿氟排泄量。所有4例患者都出现了类似的情况：肋骨、椎体和骨盆小梁骨硬化广泛消退，而皮质骨增厚以及肌肉附着点和韧带钙化基本未变。3例患者（接触后无暴露期最短者）的氟排泄量增加。这些发现表明，随着骨组织的持续重塑，小梁硬化会慢慢逆转，过量的氟会通过尿液排出。
