Mayevsky A, Zarchin N, Kaplan H, Haveri J, Haselgroove J, Chance B
Brain Res. 1983 Oct 3;276(1):95-107. doi: 10.1016/0006-8993(83)90551-6.
The interrelation between the metabolic responses to ischemia and seizure propensity was studied in two groups of seizure prone (SP) and non-seizure prone (NSP) gerbils. The metabolic state was evaluated in vivo using the light guide surface fluorometry as well as in the frozen brain scanned at liquid N2 temperature for Fp/PN ratio after monitoring the brain in vivo. The results could be summarized as follows. (1) Unilateral carotid artery occlusion led to partial ischemia in the ipsilateral hemisphere while the contralateral hemisphere remained normoxic. (2) Animal variability in the degree of the ischemia insult due to unilateral occlusion was not side dependent or in correlation with seizure propensity. (3) Significant correlation was found between the NADH increase during ischemia and the redox state measurements done in the same brain after funnel freezing with liquid nitrogen. (4) In a large number of the gerbils (not depending on the origin or strain) a peculiar inter-hemispheric blood supply connection was found. A narrow band (1 mm in width) of tissue near the midline obtained its blood via the same vessels supplying the contralateral hemisphere. (5) We did not find any correlation between blood vessel anatomy to the brain and seizure propensity.
在两组易发生癫痫（SP）和不易发生癫痫（NSP）的沙鼠中，研究了对缺血的代谢反应与癫痫发作倾向之间的相互关系。使用光导表面荧光法在体内评估代谢状态，并在对大脑进行体内监测后，在液氮温度下扫描冷冻脑以测定Fp/PN比值。结果可总结如下：（1）单侧颈动脉闭塞导致同侧半球局部缺血，而对侧半球保持正常氧合。（2）单侧闭塞引起的缺血损伤程度的动物个体差异不依赖于侧别，也与癫痫发作倾向无关。（3）发现在缺血期间NADH的增加与液氮漏斗冷冻后在同一大脑中进行的氧化还原状态测量之间存在显著相关性。（4）在大量沙鼠中（不依赖于来源或品系）发现了一种特殊的半球间血液供应连接。中线附近一条狭窄的组织带（宽度为1毫米）通过供应对侧半球的相同血管获得血液。（5）我们未发现脑血管解剖结构与癫痫发作倾向之间存在任何相关性。
