Limaye L S, Bhopale M K, Renapurkar D M, Sharma K D
Folia Parasitol (Praha). 1983;30(3):281-4.
The distribution of preadult Angiostrongylus cantonensis helminths in various regions of the central nervous system of rats, infected with varying doses of larvae, was studied. A dose of 10 000 larvae proved to be lethal; the rats showed paralytic symptoms and loss of vision prior to death. A very low dose of 15 larvae also proved to be infective to the central nervous system. Incidence of eye involvement was observed in two rats receiving a dose of 500 larvae. Maximum number of helminths were recovered from the cerebral hemisphere region but their involvement per unit weight of the tissue was found to be highest in the region of medulla oblongata.
研究了感染不同剂量幼虫的大鼠中枢神经系统各区域中广州管圆线虫未成体蠕虫的分布情况。10000条幼虫的剂量被证明是致死性的；大鼠在死亡前出现麻痹症状和视力丧失。极低剂量的15条幼虫也被证明可感染中枢神经系统。在接受500条幼虫剂量的两只大鼠中观察到眼部受累情况。从大脑半球区域回收的蠕虫数量最多，但发现延髓区域每单位组织重量中的蠕虫感染率最高。
