Kodama H, Koyama T, Takasaka M, Honjo S, Komatsu T, Yoshimura K, Machida M
Jikken Dobutsu. 1981 Jul;30(3):251-61.
Two of 80 cynomolgus monkeys, Macaca fascicularis, imported from Indonesia showed weakness, anorexia, paralysis of extremities and dysstasia. The blood test conducted at the time of autopsy proved that the white blood cell count markedly decreased in both cases and the blood urea nitrogen content increased in Case No. 1. In Case No. 2, a high blood sugar value, a low red blood cell count and a low hematocrit value were recognized. Histologic examinations revealed the presence of fragments of a nematode in the subarachnoid space of the cerebrum, granular layer of the cerebellum and gray matter of the cervical spinal cord. The findings of eosinophilic meningitis, necrosis, foreign body giant cells and cellular infiltration predominantly with eosinophils were also noted there. Morphological features of the nematode found in the tissue sections were identical, in all respects, with those described by predecessors who made morphological observations on the cross sections of Angiostrongylus cantonensis. Immunoelectrophoretic analyses of sera from these monkeys demonstrated the presence of band "a", which has been described to be highly specific to human A. cantonensis infection. Based on the above-mentioned evidences, the parasite fragments found in the histological sections from the monkeys were identified as A. cantonensis. The cases of natural infection reported herein represent the first, to our knowledge, in which migration of A. cantonensis larvae in the central nervous system of monkey was demonstrated. The present observation suggests applicability of simian angiostrongyliasis as a model for infections in man.
从印度尼西亚进口的80只食蟹猴（猕猴属）中有2只出现虚弱、厌食、肢体麻痹和运动失调症状。尸检时进行的血液检测证明，这两只猴子的白细胞计数均显著下降，病例1的血尿素氮含量升高。在病例2中，发现血糖值高、红细胞计数低和血细胞比容值低。组织学检查显示，在大脑蛛网膜下腔、小脑颗粒层和颈髓灰质中存在线虫碎片。在那里还发现了嗜酸性脑膜炎、坏死、异物巨细胞和以嗜酸性粒细胞为主的细胞浸润。在组织切片中发现的线虫形态特征在各方面均与之前对广州管圆线虫横切面进行形态观察的前人所描述的特征相同。对这些猴子血清进行的免疫电泳分析表明存在条带“a”，该条带已被描述为对人类广州管圆线虫感染具有高度特异性。基于上述证据，在猴子组织切片中发现的寄生虫碎片被鉴定为广州管圆线虫。据我们所知，本文报道的自然感染病例是首次证明广州管圆线虫幼虫在猴子中枢神经系统中迁移的病例。目前的观察结果表明，猴血管圆线虫病可作为人类感染的模型。
