Bosch J, Enriquez R, Groszmann R J, Storer E H
Hepatology. 1983 Nov-Dec;3(6):1002-7. doi: 10.1002/hep.1840030618.
Splanchnic and systemic hemodynamics were measured in six normal dogs and in 18 dogs that had the bile ducts ligated for a period of 8 weeks. In the bile duct-ligated dogs, there was a decrease in arterial pressure (110 +/- 4 mm Hg vs. normal 136 +/- 6 mm Hg; p less than 0.005) and peripheral vascular resistance (4.60 +/- 0.38 vs. 6.28 +/- 0.38 dynes-sec-cm-5; p less than 0.02), and an increase in cardiac index (129 +/- 7 vs. 98 +/- 9 ml per min per kg; p less than 0.05). The splanchnic hemodynamic characteristics in the bile duct-ligated dogs included an increase in portal venous pressure (13.3 +/- 0.6 mm Hg vs. 6.7 +/- 0.5 mm Hg; p less than 001) and wedged hepatic venous pressure (14 +/- 1.2 mm Hg), the development of extensive portal-systemic shunting (49 +/- 10 vs. 0.03 +/- 0.01%; p less than 0.01), and a decrease in portal venous flow (194 +/- 21 ml per min vs. 427 +/- 21 ml per min; p less than 0.001). This study demonstrated that chronic bile duct-ligated dogs develop sinusoidal portal hypertension with extensive portal-systemic shunting and a hyperdynamic systemic circulation. These findings closely resembled hemodynamic abnormalities observed in human cirrhosis and suggest that this model is useful in physiopathological and pharmacological studies of portal hypertension.
在6只正常犬和18只胆管结扎8周的犬中测量了内脏和全身血流动力学。在胆管结扎的犬中，动脉压降低（110±4 mmHg，正常为136±6 mmHg；p<0.005），外周血管阻力降低（4.60±0.38 vs. 6.28±0.38达因·秒·厘米⁻⁵；p<0.02），心脏指数增加（129±7 vs. 98±9 ml/分钟·千克；p<0.05）。胆管结扎犬的内脏血流动力学特征包括门静脉压升高（13.3±0.6 mmHg vs. 6.7±0.5 mmHg；p<0.001）和肝静脉楔压升高（14±1.2 mmHg），广泛的门体分流形成（49±10 vs. 0.03±0.01%；p<0.01），以及门静脉血流减少（194±21 ml/分钟 vs. 427±21 ml/分钟；p<0.001）。本研究表明，慢性胆管结扎犬会出现窦性门静脉高压，并伴有广泛的门体分流和高动力性全身循环。这些发现与人类肝硬化中观察到的血流动力学异常非常相似，表明该模型在门静脉高压的生理病理和药理研究中是有用的。
