Hollander A P, Bouman L N
J Appl Physiol. 1975 Feb;38(2):272-8. doi: 10.1152/jappl.1975.38.2.272.
The shortening of the R-R interval in response to voluntary and electrically induced isometric muscle contractions of short duration was investigated in 15 volunteers. In some of those experiments the effect of vagal blockade was also studied. The results show: 1) a lag time between the start of the contraction and the following decrease in R-R interval duration of 550 milliseconds; 2) a similar R-R interval response due to voluntary and electrically induced contractions of the same force; 3) no shortening of the R-R interval when the skin is stimulated without ensuing muscular contraction; 4) a complete disappearance of the response to isometric contractions during vagal blockade. A difference in lag time between the onset of arm contraction and cardiac acceleration could not be demonstrated. Most of the results give strong evidence to the existence of a muscle-heart reflex in man, involved in the instantaneous cardiac acceleration at the onset of exercise, that has its origin in the muscles and the vagal nerves as its efferent pathway.
对15名志愿者进行了研究，以探讨在短时间的自愿性和电诱发等长肌肉收缩时R-R间期的缩短情况。在其中一些实验中，还研究了迷走神经阻滞的影响。结果显示：1）收缩开始与随后R-R间期持续时间缩短之间的延迟时间为550毫秒；2）相同力量的自愿性收缩和电诱发收缩引起的R-R间期反应相似；3）在不伴有随后肌肉收缩的情况下刺激皮肤时，R-R间期无缩短；4）迷走神经阻滞期间对等长收缩的反应完全消失。未证实手臂收缩开始与心脏加速之间的延迟时间存在差异。大多数结果有力地证明了人体中存在肌肉-心脏反射，该反射参与运动开始时的瞬时心脏加速，其起源于肌肉，传出途径为迷走神经。
