Wright C, Kafkewitz D, Somberg E W
J Bacteriol. 1983 Nov;156(2):493-7. doi: 10.1128/jb.156.2.493-497.1983.
The effects of growth temperature on the fatty acid composition of the phospholipids of the fungus Talaromyces thermophilus were investigated. This thermophilic organism was unable to increase the degree of unsaturation of its fatty acids when shifted from high to low growth temperatures. Inhibition of fatty acid synthesis by the antibiotic cerulenin was reversed by the addition of a mixture of palmitic, stearic, and oleic acids and ergosterol. The data obtained were consistent with the hypothesis that the thermophilic character of T. thermophilus is due to metabolic limitations that restrict its ability to regulate membrane fluidity.
研究了生长温度对嗜热青霉磷脂脂肪酸组成的影响。当这种嗜热生物从高生长温度转变为低生长温度时，其无法提高脂肪酸的不饱和度。添加棕榈酸、硬脂酸、油酸和麦角固醇的混合物可逆转抗生素浅蓝菌素对脂肪酸合成的抑制作用。所获得的数据与以下假设一致：嗜热青霉的嗜热特性是由于代谢限制，从而限制了其调节膜流动性的能力。
