Cvoriscec D, Radonić M, Ceović S, Aleraj B
J Clin Chem Clin Biochem. 1983 Sep;21(9):569-71. doi: 10.1515/cclm.1983.21.9.569.
Subjects living in the endemic area of Posavina round Slavonski Brod have a significantly greater incidence of proteinuria (13.6%) than those living under the same conditions in the area where endemic nephropathy has not been observed (5.5%). Following determination of the grade and type of proteinuria, physiologic proteinuria was found in 36% of subjects from the endemic area. In nonphysiologic proteinuria the incidence of tubular proteinuria was 41%. A slight selective glomerular proteinuria was found in 51%, and other types of proteinuria in 8% of subjects. Tubular proteinuria was significantly higher in the endemic area than in the control area. The subjects with tubular proteinuria from the endemic area excrete significantly greater amounts of beta 2-microglobulin and light immunoglobulin chains.
生活在斯拉沃尼亚布罗德周边波萨维纳病区的人群蛋白尿发病率（13.6%）显著高于生活在未观察到地方性肾病地区相同条件下的人群（5.5%）。在确定蛋白尿的分级和类型后，发现病区36%的受试者存在生理性蛋白尿。在非生理性蛋白尿中，肾小管性蛋白尿的发生率为41%。51%的受试者存在轻度选择性肾小球性蛋白尿，8%的受试者存在其他类型的蛋白尿。病区的肾小管性蛋白尿显著高于对照地区。来自病区的肾小管性蛋白尿受试者排泄的β2-微球蛋白和轻免疫球蛋白链的量显著更多。
