Radonić M, Cvorisćec D, Borso G, Stavljenić A, Ceović S
Medical Department, Zagreb University School of Medicine, Yugoslavia.
Urol Res. 1988;16(5):377-80. doi: 10.1007/BF00256046.
Data on the excretion of Tamm-Horsfall protein (THP) in subjects living in an area of Balkan endemic nephropathy (BEN) are reported. The study subjects were divided into groups as follows: diseased, suspect, "at risk" and others, according to previously adopted criteria. The THP excretion in "at risk" subjects was found to be significantly higher as compared to control subjects. The difference between these two groups could not be registered by any other clinical or laboratory diagnostic methods. No difference in the excretion of THP was observed between the groups of others and control subjects. According to the results obtained, the excretion of THP may be considered a possibly useful additional diagnostic test for the detection of subjects with the latent, early subclinical phase of BEN. On the other hand, the data obtained shed some more light on the still obscure pathogenesis and natural history of BEN.
报道了关于生活在巴尔干地方性肾病（BEN）地区人群中Tamm-Horsfall蛋白（THP）排泄情况的数据。根据先前采用的标准，研究对象被分为以下几组：患病组、疑似组、“有风险”组和其他组。发现“有风险”组的THP排泄量与对照组相比显著更高。这两组之间的差异无法通过任何其他临床或实验室诊断方法检测到。其他组和对照组之间未观察到THP排泄的差异。根据所获得的结果，THP排泄可被视为一种可能有用的额外诊断测试，用于检测处于BEN潜伏、早期亚临床阶段的患者。另一方面，所获得的数据为BEN仍然模糊不清的发病机制和自然史提供了更多线索。
