肺癌患者对汤姆森 - 弗里德赖希（T）抗原的自身免疫反应：诊断效用
Lung cancer patients' autoimmune responses to Thomsen-Friedenreich (T) antigen: diagnostic utility.
作者信息
Fry W A, Springer G F, Desai P R
出版信息
Klin Wochenschr. 1983 Aug 15;61(16):817-8. doi: 10.1007/BF01496727.
The usefulness of T antigen in the diagnosis of lung cancer (LCA), including early, was assessed by determining the in vitro delayed type hypersensitivity response to T(DTHR-T), and by measuring with a solid phase immunofluorescent assay the serum anti-T IgM response. Sensitivity of DTHR-T was 89% for 73 patients with LCA including 8/9 with Stage T1N0M0 disease, overall specificity was 95% for 212 healthy persons and those with non-CA disease. The humoral immune assay detected 31/35 (89%) LCA patients including 4/5 Stage T1N0M0 patients. Overall specificity was greater than 90% among 116 persons without CA.
通过测定对T抗原的体外迟发型超敏反应（T抗原迟发型超敏反应，DTHR-T）以及采用固相免疫荧光测定法检测血清抗T IgM反应，评估了T抗原在包括早期肺癌（LCA）在内的肺癌诊断中的效用。对于73例LCA患者（包括9例T1N0M0期疾病患者中的8例），DTHR-T的敏感性为89%；对于212名健康人和非癌症疾病患者，总体特异性为95%。体液免疫测定法检测出35例LCA患者中的31例（89%），包括5例T1N0M0期患者中的4例。在116名无癌症患者中，总体特异性大于90%。
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