Summers J L, Coon J S, Ward R M, Falor W H, Miller A W, Weinstein R S
Cancer Res. 1983 Feb;43(2):934-9.
Several markers of initial bladder carcinomas described recently may be clinically significant predictors of biological behavior of future recurrences. Comparison of the marker systems and assessment of the value of using multiple markers have been difficult, because the various markers have been studied in different patients. In this study, we compared four markers [chromosome mode, marker chromosomes, and expression of the ABH "blood group" antigens and the Thomsen-Friedenreich antigen (using immunoperoxidase or lectin immunoperoxidase methods)] in 39 patients presenting initially with low-stage bladder carcinoma and followed 3 to 11 years or until deep muscle invasion occurred. Each of the markers was significantly related to subsequent recurrences with deep muscle invasion, and each marker system was able to identify those patients with a very low risk of subsequent invasion. For detection of a subpopulation of patients with Grade II carcinomas who were at high risk for development of subsequent invasion, combinations of markers, especially hyperdiploidy and abnormal expression of the Thomsen-Friedenreich antigen, were significantly more effective than any single marker system.
最近描述的几种原发性膀胱癌标志物可能是未来复发生物学行为的临床重要预测指标。由于各种标志物是在不同患者中进行研究的，因此比较标志物系统以及评估使用多种标志物的价值一直很困难。在本研究中，我们对39例初发低分期膀胱癌患者的四种标志物[染色体模式、标记染色体以及ABH“血型”抗原和汤姆森-弗里德赖希抗原的表达（使用免疫过氧化物酶或凝集素免疫过氧化物酶方法）]进行了比较，并对其随访3至11年，或直至发生深部肌肉浸润。每种标志物均与随后发生深部肌肉浸润的复发显著相关，且每个标志物系统都能够识别出随后发生浸润风险极低的患者。对于检测II级癌患者中随后发生浸润风险高的亚组，标志物组合，尤其是超二倍体和汤姆森-弗里德赖希抗原的异常表达，比任何单一标志物系统都显著更有效。
