Pavlov A S, Datsenko V S, Fadeeva M A
Med Radiol (Mosk). 1983 Oct;28(10):14-8.
Proceeding from radiobiological data, the TDF concept and a cumulative radiation effect the authors proposed a new variant of preoperative radiotherapy in operable breast cancer patients. Single doses for the breast and axillary-subclavicular zone that were 15 and 12.5 Gy, were determined. Observation over 72 patients showed that single irradiation did not influence the course of operation and the postoperative period. Good functional and short-term results of treatment make it possible to recommend single large fraction preoperative irradiation for trials in special oncological and radiological institutions.
基于放射生物学数据、TDF概念和累积辐射效应，作者提出了一种可手术乳腺癌患者术前放疗的新方案。确定了乳房和腋窝-锁骨下区域的单次剂量分别为15 Gy和12.5 Gy。对72例患者的观察表明，单次照射不影响手术过程和术后恢复。良好的功能和短期治疗效果使得推荐单次大分割术前照射在特殊肿瘤和放射机构进行试验成为可能。
