乙醇对人体影响的昼夜节律变化。

Circadian variation in effects of ethanol in man.

作者信息

Lawrence N W, Herbert M, Jeffcoate W J

出版信息

Pharmacol Biochem Behav. 1983;18 Suppl 1:555-8. doi: 10.1016/0091-3057(83)90235-6.

Abstract

Twenty normal male volunteers received an intoxicating dose of oral ethanol (2 ml/kg vodka) and impairment of psychological functioning was documented over the succeeding 90 min. Half the subjects received ethanol at 0900 hr and half at 1800 hr. Those who received ethanol in the morning performed worse in tests of reaction time (p less than 0.002) and logical reasoning (p less than 0.002), even though blood alcohol levels were similar in the two groups. It is concluded that there is a circadian rhythm in the effects of ethanol in man.

摘要

20名正常男性志愿者口服了致醉剂量的乙醇（2毫升/千克伏特加），并记录了随后90分钟内心理功能的损害情况。一半受试者在上午9点摄入乙醇，另一半在下午6点摄入。上午摄入乙醇的受试者在反应时间测试（p<0.002）和逻辑推理测试（p<0.002）中的表现更差，尽管两组的血液酒精水平相似。得出的结论是，乙醇对人体的影响存在昼夜节律。