Chan A W, Schanley D L, Leong F W
Pharmacol Biochem Behav. 1983 Aug;19(2):275-80. doi: 10.1016/0091-3057(83)90052-7.
C57BL/6J mice, after having been exposed to a free-choice condition between water and aqueous chlordiazepoxide (CDP, 25 mg/100 ml) or between water and ethanol/CDP, showed a significant trend for decreased preference for ethanol when tested 2 weeks later. Similarly, mice previously exposed to a no-choice intake of ethanol showed a significant decrease in ethanol preference when tested subsequently. A long-lasting (greater than 20 weeks) reduction in ethanol selection developed after mice were previously exposed to ethanol/CDP in a no-choice condition. This was also accompanied by a decrease in the subsequent selection of ethanol/CDP, but not CDP. The exact mechanisms for the long-lasting decrease in ethanol selection was unknown, but it was not due to the development of fluid aversion. It is suggested that the combined central effects of ethanol/CDP might be partially responsible.
C57BL/6J小鼠在经历水与氯氮卓水溶液（CDP，25毫克/100毫升）之间的自由选择条件，或水与乙醇/CDP之间的自由选择条件后，在2周后进行测试时，对乙醇的偏好显示出显著的下降趋势。同样，先前经历无选择摄入乙醇的小鼠在随后进行测试时，对乙醇的偏好也显著降低。在小鼠先前在无选择条件下接触乙醇/CDP后，出现了对乙醇选择的长期（超过20周）减少。这还伴随着随后对乙醇/CDP选择的减少，但对CDP的选择没有减少。乙醇选择长期减少的确切机制尚不清楚，但并非由于形成了液体厌恶。有人认为，乙醇/CDP的联合中枢效应可能部分起了作用。
