Chan A W, Schanley D L, Aleo M D, Leong F W
Alcohol. 1985 Mar-Apr;2(2):209-13. doi: 10.1016/0741-8329(85)90047-3.
Drug-induced hypothermia was used to investigate drug tolerance and cross-tolerance. C57BL/6J mice, which were injected with a single dose of chlordiazepoxide (CDP; 30 mg/kg) one day before and reinjected with an equivalent dose of CDP the next day, did not develop tolerance to the drug. However, ethanol-pretreated (3.5 g/kg, 24 hr earlier) mice, when injected with CDP (30 mg/kg), showed cross-tolerance to CDP. The cross-tolerance was short-lived (less than 48 hr). On the other hand, CDP-pretreated mice (30 mg/kg, 24 hr earlier) did not show cross-tolerance to ethanol. The lack of a reciprocating effect of CDP-pretreatment was not likely to be due to the difference in initial dosage between ethanol and CDP. It may be due to different rates of tolerance development or different mechanisms of actions between CDP and ethanol. Mice chronically treated with ethanol also showed a similar degree of cross-tolerance to CDP compared to those exposed to an acute dose of ethanol.
药物诱导的体温过低被用于研究药物耐受性和交叉耐受性。C57BL/6J小鼠，在一天前注射单剂量的氯氮卓（CDP；30毫克/千克），并在第二天再次注射等量的CDP，对该药物未产生耐受性。然而，乙醇预处理（3.5克/千克，提前24小时）的小鼠，在注射CDP（30毫克/千克）时，对CDP表现出交叉耐受性。这种交叉耐受性是短暂的（小于48小时）。另一方面，CDP预处理的小鼠（30毫克/千克，提前24小时）对乙醇未表现出交叉耐受性。CDP预处理缺乏相互作用的效应不太可能是由于乙醇和CDP初始剂量的差异。这可能是由于耐受性发展的速率不同或CDP与乙醇之间的作用机制不同。与急性剂量乙醇处理的小鼠相比，长期用乙醇处理的小鼠对CDP也表现出相似程度的交叉耐受性。
