氯氮䓬对小鼠酒精摄入量的影响。
Influence of chlordiazepoxide on alcohol consumption in mice.
作者信息
Chan A W, Leong F W, Schanley D L
出版信息
Pharmacol Biochem Behav. 1983 May;18(5):797-802. doi: 10.1016/0091-3057(83)90025-4.
In a free-choice situation, chlordiazepoxide (CDP; 12.5 or 25 mg/100 ml; groups B or C), when incorporated in ethanol solutions (2 to 20%, v/v), caused a significant decrease in ethanol preference index (P.I.). This was probably due to the combined CNS effects of both drugs rather than a taste effect, since the mice did not discriminate between aqueous CDP solutions and water. However, when the mice had prior exposure to ethanol and CDP was incorporated intermittently, no significant decreases in P.I. resulted. In a no-choice situation, ethanol intake was increased only on the first day of each intermittent incorporation of CDP (3 days for each 6-day cycle), being more persistent in group B (2 to 15% ethanol) than in group C (2 to 6.5%). Ethanol intake decreased in group C when alcohol concentrations exceeded 10%. The "first-day" CDP effect also occurred in the no-choice situation of an ethanolic liquid diet. Possible factors for this effect are discussed. Thus the effects of CDP on alcohol consumption in non-deprived mice vary with experimental designs.
在自由选择的情况下，当将氯氮卓（CDP；12.5或25毫克/100毫升；B组或C组）加入乙醇溶液（2%至20%，体积/体积）中时，乙醇偏好指数（P.I.）显著降低。这可能是由于两种药物对中枢神经系统的联合作用，而非味觉效应，因为小鼠无法区分CDP水溶液和水。然而，当小鼠预先接触过乙醇且间歇性加入CDP时，P.I.并未显著降低。在无选择的情况下，仅在每次间歇性加入CDP的第一天（每6天周期中有3天）乙醇摄入量增加，B组（2%至15%乙醇）比C组（2%至6.5%）更持久。当酒精浓度超过10%时，C组的乙醇摄入量减少。“第一天”的CDP效应在乙醇液体饮食的无选择情况下也会出现。文中讨论了造成这种效应的可能因素。因此，CDP对未被剥夺的小鼠酒精摄入量的影响因实验设计而异。
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