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自发性高血压大鼠的运动活动、听觉惊跳反应和休克阈值

Locomotor activity, auditory startle and shock thresholds in spontaneously hypertensive rats.

作者信息

Leaton R N, Cassella J V, Whitehorn D

出版信息

Physiol Behav. 1983 Jul;31(1):103-9. doi: 10.1016/0031-9384(83)90103-8.

DOI:10.1016/0031-9384(83)90103-8
PMID:6634969
Abstract

A group of SHRs and a group of WKY normotensive controls were compared sequentially on open-field behavior, Y-maze activity, responsiveness and habituation of the auditory startle response, and shock thresholds. In the open field and Y maze the SHRs were more active than the WKYs, but the locomotor activity of the SHRs decreased more within sessions. However, the SHRs could be described as showing more, less or the same between-session habituation depending upon the apparatus and the portion of the session analyzed. The SHRs were less responsive than controls on the auditory startle response measure, and they did not differ from controls on startle-response habituation. The SHRs were less responsive than controls at low shock levels but more responsive at high shock levels. The relationship between SHRs and WKYs on the responsiveness dimension depended upon the modality and intensity of the stimulus, the response characteristics of the test situation, and the time sample of behavior taken.

摘要

对一组自发性高血压大鼠(SHRs)和一组正常血压的WKY对照大鼠,依次比较其旷场行为、Y迷宫活动、听觉惊跳反应的反应性和习惯化以及电击阈值。在旷场和Y迷宫中,SHRs比WKYs更活跃,但SHRs在实验过程中的运动活动下降得更多。然而,根据所使用的仪器和分析的实验部分,SHRs在实验过程中的习惯化程度可能表现为更多、更少或相同。在听觉惊跳反应测量中,SHRs的反应性低于对照组,且在惊跳反应习惯化方面与对照组无差异。在低电击水平下,SHRs的反应性低于对照组,但在高电击水平下反应性更高。SHRs和WKYs在反应性维度上的关系取决于刺激的模态和强度、测试情境的反应特征以及所采集行为的时间样本。

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