Nelson D, Henningsen N C
Scand J Clin Lab Invest. 1983 Jun;43(4):317-22.
Erythrocyte sodium, potassium, zinc and magnesium were measured in 56 male offspring to essential hypertensive patients and compared with 46 matched controls. The same parameters were measured again 4-6 months apart in 31 offspring and eight controls. Intracellular sodium was significantly higher in offspring (P less than 0.001). There was a highly significant correlation between the two intra-individual measurements of intracellular sodium, potassium and zinc but not for magnesium. Sodium in erythrocytes is probably an indicator of the activity of the sodium-pump and could possibly be used as a genetic marker in the future investigations of individuals with heredity for severe, essential hypertension.
对56名原发性高血压患者的男性后代进行了红细胞钠、钾、锌和镁的测量，并与46名匹配的对照者进行了比较。在31名后代和8名对照者中，相隔4 - 6个月再次测量相同参数。后代的细胞内钠显著更高（P小于0.001）。细胞内钠、钾和锌的两次个体内测量之间存在高度显著的相关性，但镁不存在。红细胞中的钠可能是钠泵活性的一个指标，并且在未来对严重原发性高血压遗传个体的研究中可能用作遗传标记。
