Barta O, Breitschwerdt E B, Shaffer L M, Pourciau S S
Am J Vet Res. 1983 Oct;44(10):1954-9.
Serum protein concentrations and 4 immunologic factors were determined in 5 Basenji dogs with immunoproliferative small intestinal disease. There was no correlation between the total serum proteins, immunoglobulin G and immunoglobulin M concentrations, and physical health status of the animals. The severity of clinical signs correlated roughly with decrease in albumin and increase in globulin concentrations. The main changes were detected in beta- and fast gamma-globulins. The total hemolytic complement levels were decreased in the 2 most severely affected animals below the minimal laboratory values observed in healthy animals. Alteration in the intrinsic responsiveness of lymphocytes to various mitogens did not correlate with progression in severity of the disease. Correlation between the appearance of blastogenesis-suppressing substances in serum and the severity of the disease was only partial: Sera (at 20% concentration) from the 2 most severely affected dogs completely suppressed blastogenesis induced by all 3 mitogens. The sera of 3 other dogs either did not suppress or suppressed only concanavalin A-induced mitogenesis and to a lesser extent phytohemagglutinin-induced mitogenesis without correlations to the overall clinical status. The disturbances of immunologic mechanisms were detected after the appearance of clinical disease, were not considered the cause of immunoproliferative small intestinal disease, may represent a manifestation of the secondary infection, and may contribute to aggravation of the clinical course.
对5只患有免疫增殖性小肠疾病的巴仙吉犬测定了血清蛋白浓度和4种免疫因子。动物的血清总蛋白、免疫球蛋白G和免疫球蛋白M浓度与身体健康状况之间无相关性。临床症状的严重程度大致与白蛋白降低和球蛋白浓度升高相关。主要变化见于β球蛋白和快速γ球蛋白。2只受影响最严重的动物的总溶血补体水平降至健康动物观察到的最低实验室值以下。淋巴细胞对各种有丝分裂原的内在反应性改变与疾病严重程度的进展无关。血清中抑制增殖物质的出现与疾病严重程度之间仅存在部分相关性：2只受影响最严重的犬的血清（浓度为20%）完全抑制了由所有3种有丝分裂原诱导的增殖。其他3只犬的血清要么不抑制，要么仅抑制刀豆球蛋白A诱导的有丝分裂，对植物血凝素诱导的有丝分裂抑制程度较小，且与总体临床状况无关。免疫机制紊乱在临床疾病出现后才被检测到，不被认为是免疫增殖性小肠疾病的病因，可能是继发感染的一种表现，且可能导致临床病程加重。
