Buchet J P, Roels H, Lauwerys R
Toxicology. 1978 Apr;9(4):361-9. doi: 10.1016/0300-483x(78)90019-7.
Following oral administration of lead a difference in free erythrocyte protoporphyrin (FEP) increase was found between adult male, adult female and suckling rats: young animals are more susceptible than adult female rats which in turn exhibit a greater FEP increase than adult male animals. This observation parallels that made previously in humans. Possible difference in iron metabolism does not appear to explain the sex-linked difference in FEP response to lead. Sex hormones mainly progesterone, seem to play a role but their interaction with lead on the FEP response is restricted to female rats and apparently is not mediated through changes in delta-aminolevulinic acid synthetase activity.
口服铅后，成年雄性、成年雌性和乳鼠的游离红细胞原卟啉（FEP）升高存在差异：幼龄动物比成年雌性大鼠更易受影响，而成年雌性大鼠FEP的升高又比成年雄性动物更大。这一观察结果与之前在人类中的观察结果相似。铁代谢的可能差异似乎无法解释FEP对铅反应的性别关联差异。性激素（主要是孕酮）似乎起了作用，但它们与铅在FEP反应上的相互作用仅限于雌性大鼠，且显然不是通过δ-氨基乙酰丙酸合成酶活性的变化介导的。
