Susini C, Esteve J P, Vaysse N, Pradayrol L, Ribet A
Gastroenterology. 1980 Oct;79(4):720-4.
The effect of somatostatin 28, a noval intestinal peptide containing somatostatin in its C-terminal portion, was tested on basal exocrine pancreatic secretion on conscious dogs and after stimulation by secretin (1 CU x kg-1 x hr-1), caerulein (37.5 ng x kg-1 x hr-1) or secretin (2 CU x kg-1 x hr-1) caerulein (37.5 ng x kg-1 x hr-1). We found differences in the inhibitory effect of somatostatin 28 on these three forms of stimulation. Bicarbonate secretion stimulated by secretin was inhibited only slightly by large doses of somatostatin 28, whereas small doses markedly inhibited stimulation by caerulein. Protein concentrations were inhibited only when secretin was the stimulant. Protein outputs to all forms of stimulation were inhibited. When compared with synthetic somatostatin 14, lower doses of somatostatin 28 were required to produce the same inhibitory effect on protein outputs stimulated by secretin alone and on volumes stimulated by caerulein alone.
生长抑素28是一种新型肠肽，其C末端部分含有生长抑素，我们在清醒犬身上测试了它对基础胰腺外分泌的影响，以及在促胰液素（1 CU·kg⁻¹·hr⁻¹）、蛙皮素（37.5 ng·kg⁻¹·hr⁻¹）或促胰液素（2 CU·kg⁻¹·hr⁻¹）加蛙皮素（37.5 ng·kg⁻¹·hr⁻¹）刺激后的影响。我们发现生长抑素28对这三种刺激形式的抑制作用存在差异。大剂量的生长抑素28仅轻微抑制促胰液素刺激的碳酸氢盐分泌，而小剂量则显著抑制蛙皮素的刺激。仅当促胰液素作为刺激物时，蛋白质浓度受到抑制。所有刺激形式下的蛋白质输出均受到抑制。与合成生长抑素14相比，较低剂量的生长抑素28就能对单独促胰液素刺激的蛋白质输出以及单独蛙皮素刺激的分泌量产生相同的抑制作用。
