Leith N J
Brain Res. 1983 Oct 24;277(1):129-36. doi: 10.1016/0006-8993(83)90914-9.
The effects of apomorphine (APO) on self-stimulation responding were examined as a function of drug dose and stimulation current intensity. The lowest dose tested (0.02 mg/kg) significantly elevated the stimulation threshold, presumably reflecting the drug's preferential affinity for presynaptic dopamine (DA) receptors at this dose. At a dose which stimulates postsynaptic DA receptors (0.2 mg/kg), the rats responded with a pattern of behavior that resembled that obtained when non-drugged animals are given non-contingent current. However, during extinction, drugged animals were identical to non-drugged rats in their pattern of responding. These data indicate an interaction of APO with the stimulating current and suggest that APO may be mimicking only one component of the stimulation--perhaps the rewarding but not the motivating one.
研究了阿扑吗啡（APO）对自我刺激反应的影响，并将其作为药物剂量和刺激电流强度的函数。所测试的最低剂量（0.02毫克/千克）显著提高了刺激阈值，这可能反映了该剂量下药物对突触前多巴胺（DA）受体的优先亲和力。在刺激突触后DA受体的剂量（0.2毫克/千克）下，大鼠的行为模式类似于未给药动物接受非条件电流时的行为模式。然而，在消退过程中，给药动物的反应模式与未给药大鼠相同。这些数据表明APO与刺激电流之间存在相互作用，并表明APO可能仅模拟刺激的一个组成部分——也许是奖励部分而非激励部分。
