Carey R J
Pharmacol Biochem Behav. 1982 May;16(5):859-61. doi: 10.1016/0091-3057(82)90250-7.
The effect of three doses of apomorphine 0.125, 0.25 and 0.5 were studied on self-stimulation generated by three levels of current intensity. Eight rats exhibited overall dose dependent decreases in self-stimulation obtained at the two lowest current intensities. Self-stimulation at the highest current intensity, however, was unaffected by even the highest dose level of apomorphine (0.5 mg/kg) despite typical signs of stereotypy exhibited by the rats in their home cages. Additionally, self-stimulation obtained under the 0.5 mg/kg dose of apomorphine under went extinction when reinforcement was discontinued. Thus, brain stimulation can be an effective reinforcement when an animal is given a stereotypy inducing dose of apomorphine if the current intensity is of sufficient magnitude and if the response manipulandum is not compatible with stereotypic responses. These observations appear consistent with a dopaminergic involvement in the response rather than reinforcement aspect of self-stimulation.
研究了三种剂量（0.125、0.25和0.5）的阿扑吗啡对三种电流强度水平下自我刺激行为的影响。八只大鼠在两种最低电流强度下获得的自我刺激表现出总体剂量依赖性降低。然而，即使在最高剂量水平（0.5 mg/kg）的阿扑吗啡作用下，最高电流强度下的自我刺激也未受影响，尽管大鼠在其饲养笼中表现出典型的刻板行为迹象。此外，当强化停止时，在0.5 mg/kg剂量阿扑吗啡作用下获得的自我刺激行为发生消退。因此，如果电流强度足够大且反应操作装置与刻板反应不兼容，当给动物给予诱导刻板行为剂量的阿扑吗啡时，脑刺激可以成为一种有效的强化方式。这些观察结果似乎与多巴胺能参与自我刺激的反应而非强化方面一致。
