Hall F S, Stellar J R
Department of Psychology, Northeastern University, Boston, MA 02215, USA.
Pharmacol Biochem Behav. 1996 Feb;53(2):417-23. doi: 10.1016/0091-3057(95)02007-1.
The direct dopamine agonist apomorphine has been reported to reduce the rewarding efficacy of lateral hypothalamic (LH) self-stimulation. This effect has been claimed to support the notion that dopamine mediates the rewarding effects of LH self-stimulation. Using a standard rate-frequency curve-shift paradigm with ascending order of frequency presentation, we also found that apomorphine (0.1-0.8 mg/kg, SC) appeared to decrease LH self-stimulation reward. These apparent rightward curve shifts were exacerbated by shortening the test duration, which also produced a number of sessions in which the subjects did not respond at all. When the presentation order of stimulation frequencies was reversed, apomorphine did not produce large reward decreases. These results suggest that the previously reported effects of apomorphine on LH self-stimulation were the result of artifact, perhaps related to apomorphine-induced stereotypical behavior combined with rapid pharmacological recovery.
据报道，直接多巴胺激动剂阿扑吗啡可降低下丘脑外侧（LH）自我刺激的奖赏效力。这一效应被认为支持了多巴胺介导LH自我刺激奖赏效应的观点。使用频率呈现顺序递增的标准速率-频率曲线移动范式，我们还发现阿扑吗啡（0.1-0.8毫克/千克，皮下注射）似乎会降低LH自我刺激奖赏。缩短测试持续时间会加剧这些明显的曲线右移，这也导致出现了一些受试者完全没有反应的实验阶段。当刺激频率的呈现顺序颠倒时，阿扑吗啡并没有导致奖赏大幅降低。这些结果表明，先前报道的阿扑吗啡对LH自我刺激的效应是人为因素的结果，可能与阿扑吗啡诱导的刻板行为以及快速的药理学恢复有关。
