Hosenpud J D, Greenberg B H
Chest. 1983 Dec;84(6):690-4. doi: 10.1378/chest.84.6.690.
We retrospectively compared clinical assessment and cardiac catheterization to subsequent surgical findings with regard to specific valvular involvement, hemodynamic status, and presence of myocardial abscess in patients recommended for cardiac surgery for endocarditis. Of 105 consecutive patients with endocarditis, 19 met one or more of the following criteria suggesting the need for early surgery: congestive heart failure; systemic emboli; persistent infections or new conduction abnormalities. Of these 19 patients, seven had prosthetic cardiac valves. Clinical assessment was highly sensitive (95 percent) and specific (89 percent) for specific valvular involvement and was also highly sensitive and specific in evaluating myocardial abscess and congestive heart failure; however, clinical assessment could not identify the source of infection in one patient with multiple prosthetic valves, did not define the specific valve in one patient with right-sided endocarditis, and overestimated the severity of mitral regurgitation in one patient who had normal pressures and flows at catheterization. Catheterization incorrectly predicted multivalvular involvement in four patients. At catheterization, only one patient experienced evidence of clinical deterioration, and this was probably not related to the procedure. We conclude that although clinical assessment is correct in most patients, it may on occasion lead to an erroneous conclusion. Catheterization and angiograms are of value in the preoperative evaluation of patients with endocarditis, particularly in cases where the clinical assessment is ambiguous or uncertain. The procedures can be performed at low risk, and the information obtained may substantially influence management in some cases.
我们对因感染性心内膜炎而建议进行心脏手术的患者,就特定瓣膜受累情况、血流动力学状态以及心肌脓肿的存在,回顾性地比较了临床评估及心导管检查结果与后续手术所见。在连续105例感染性心内膜炎患者中,19例符合一项或多项提示需早期手术的下列标准:充血性心力衰竭;全身性栓塞;持续感染或新出现的传导异常。在这19例患者中,7例有人造心脏瓣膜。临床评估对于特定瓣膜受累具有高度敏感性(95%)和特异性(89%),在评估心肌脓肿和充血性心力衰竭方面也具有高度敏感性和特异性;然而,临床评估无法确定一名有多个人造瓣膜患者的感染源,无法明确一名右侧心内膜炎患者的具体瓣膜,并且高估了一名心导管检查时压力和血流正常患者的二尖瓣反流严重程度。心导管检查错误地预测了4例多瓣膜受累情况。在心导管检查时,只有1例出现临床病情恶化的证据,而这可能与该操作无关。我们得出结论,尽管临床评估在大多数患者中是正确的,但偶尔可能会导致错误结论。心导管检查和血管造影在感染性心内膜炎患者的术前评估中具有价值,特别是在临床评估不明确或不确定的情况下。这些操作风险较低,并且所获得的信息在某些情况下可能会对治疗管理产生重大影响。