Thomas D, Desruennes M, Jault F, Isnard R, Gandjbakhch I
Service de cardiologie, groupe hospitalier Pitié-Salpêtrière, Paris.
Arch Mal Coeur Vaiss. 1993 Dec;86(12 Suppl):1825-35.
Cardiac abscesses are observed in 20 to 30% of cases of infective endocarditis and in at least 60% of prosthetic valve endocarditis. The aortic valve ring is more frequently affected than the mitral valve ring. A cavity contiguous with a cardiac chamber forming a pseudo-aneurysm or a closed purulent collection, the abscess may extend to the neighbouring cardiac structures or to the ascending aorta. This extension may cause conduction defects, abnormal communications between the cardiac chambers, pericardial disease and, exceptionally, myocardial ischaemia, complications which are clinical signs of abscess formation in patients with infective endocarditis. The presence of a cardiac abscess is a poor prognostic factor in infective endocarditis. The diagnosis must be made at an early stage when surgical treatment is optimal. The most valuable investigation is transoesophageal echocardiography with a sensitivity of over 80% and a specificity of about 95%. This investigation has become practically routine in all patients with endocarditis in order to diagnose abscesses at an early stage, especially in cases of aortic or prosthetic valve endocarditis. Information about the site, size and extension of the abscess may be obtained and existing or potential complications may be envisaged with a view to surgery. Other imaging diagnostic techniques, such as angiography, CT scanning and nuclear magnetic resonance imaging have a number of disadvantages and are not more sensitive than transoesophageal echocardiography. Surgical techniques depend on the site and extension of the abscess. They are sutured or closed with dacron or pericardial patches after having been cleaned and filled with formulated resorcin glue. The valvular prosthesis is inserted either in anatomical position or in a sub or supracoronary dacron tube necessitated by the perivalvular extension of the infectious lesions. These complex procedures may require associated coronary reimplantation or revascularisation when the coronary ostia are affected. The highest operative mortality is observed in prosthetic valve endocarditis with abscess and extra-annular prosthetic implants. The risk of secondary valvular dehiscence, often recurrent, is much higher when there is an abscess at operation. Extracardiac abscesses in cases of infective endocarditis are mainly observed in the cerebral and/or splenic territories. They may become the main problem, especially cerebral abscesses, but they rarely require surgery.
在20%至30%的感染性心内膜炎病例以及至少60%的人工瓣膜心内膜炎病例中可观察到心脏脓肿。主动脉瓣环比二尖瓣环更常受累。脓肿是一个与心腔相邻的腔隙,形成假性动脉瘤或封闭的脓性积液,可延伸至邻近的心脏结构或升主动脉。这种延伸可能导致传导缺陷、心腔之间的异常交通、心包疾病,以及罕见的心肌缺血,这些并发症是感染性心内膜炎患者脓肿形成的临床征象。心脏脓肿的存在是感染性心内膜炎的一个不良预后因素。必须在手术治疗最佳的早期阶段做出诊断。最有价值的检查是经食管超声心动图,其敏感性超过80%,特异性约为95%。为了早期诊断脓肿,尤其是在主动脉或人工瓣膜心内膜炎的病例中,这项检查在所有心内膜炎患者中已几乎成为常规检查。可以获得有关脓肿部位、大小和延伸情况的信息,并可设想现有或潜在的并发症,以便进行手术。其他影像学诊断技术,如血管造影、CT扫描和核磁共振成像有许多缺点,且不比经食管超声心动图更敏感。手术技术取决于脓肿的部位和延伸情况。在清理并用配制的吸收性胶水填充后,用涤纶或心包补片缝合或封闭脓肿。根据感染性病变的瓣周延伸情况,将人工瓣膜假体置于解剖位置或置于冠状动脉下或冠状动脉上的涤纶管中。当冠状动脉开口受累时,这些复杂的手术可能需要联合冠状动脉再植入或血管重建。在伴有脓肿和瓣环外人工植入物的人工瓣膜心内膜炎中观察到最高的手术死亡率。手术时有脓肿时,继发性瓣膜裂开的风险,通常是复发性的,要高得多。感染性心内膜炎病例中的心脏外脓肿主要见于脑和/或脾区域。它们可能成为主要问题,尤其是脑脓肿,但很少需要手术。