Lung tissue concentrations of cefoperazone.

The following lung tissue concentrations of cefoperazone were found in 20 patients after a 2 g single dose: 45.3-113.3 mg/kg after one hour and 20.5-68.1 mg/kg after two hours. The respective serum levels were measured in parallel determinations for comparison purposes. All determinations were carried out by means of high pressure liquid chromatography. The results suggest that cefoperazone has a rapid and sustained concentration ability in the lung tissue. The drug is therefore suitable for perioperative prophylaxis in lung surgery.