Wartenberg K, Tonak J, Knapp W
Infection. 1983 Sep-Oct;11(5):280-2. doi: 10.1007/BF01641263.
The following lung tissue concentrations of cefoperazone were found in 20 patients after a 2 g single dose: 45.3-113.3 mg/kg after one hour and 20.5-68.1 mg/kg after two hours. The respective serum levels were measured in parallel determinations for comparison purposes. All determinations were carried out by means of high pressure liquid chromatography. The results suggest that cefoperazone has a rapid and sustained concentration ability in the lung tissue. The drug is therefore suitable for perioperative prophylaxis in lung surgery.
在20例患者单次静脉注射2g头孢哌酮后，测得肺组织中的药物浓度如下：给药后1小时为45.3～113.3mg/kg，2小时为20.5～68.1mg/kg。同时测定血清药物浓度以便比较。所有测定均采用高效液相色谱法。结果表明，头孢哌酮在肺组织中有迅速而持久的浓度维持能力。因此，该药适用于肺部手术的围手术期预防用药。
