Braga P C, Scaglione F, Villa S, Scarpazza G, Gagliardi V, Biella G, Manganelli V, Paiola G, Fraschini F
Int J Clin Pharmacol Res. 1983;3(5):349-55.
Cefoperazone is a third-generation semisynthetic injectable cephalosporin. It has been reported that cefoperazone has beta-lactamase resistance and quite a broad antimicrobial spectrum against many Gram-positive and Gram-negative microorganisms and most anaerobes. In this study, the pharmacokinetics of cefoperazone were examined in a group of 10 patients suffering from acute exacerbations of chronic bronchitis, with purulent or mucopurulent expectorations. Cefoperazone was administered at the dose of 1 g i.m. every 12 hours. Serum and urinary parameters and the profile of bronchial mucus diffusion were assessed after the first administration and during the whole period of treatment which lasted for 7 days. In a second, third, and fourth group of volunteer patients who had to undergo surgical operations, bone, lung and prostatic penetration of cefoperazone was determined in correlation with serum levels.
头孢哌酮是一种第三代半合成注射用头孢菌素。据报道，头孢哌酮具有β-内酰胺酶抗性，对许多革兰氏阳性和革兰氏阴性微生物以及大多数厌氧菌具有相当广泛的抗菌谱。在本研究中，对一组10例患有慢性支气管炎急性加重且伴有脓性或黏液脓性痰的患者进行了头孢哌酮的药代动力学研究。头孢哌酮以每12小时1g的剂量肌肉注射给药。在首次给药后以及持续7天的整个治疗期间，评估了血清和尿液参数以及支气管黏液扩散情况。在第二、第三和第四组必须接受外科手术的志愿者患者中，测定了头孢哌酮在骨骼、肺部和前列腺的渗透情况及其与血清水平的相关性。
