Scharf M B, Khosla N, Lysaght R, Brocker N, Moran J
J Clin Psychiatry. 1983 Oct;44(10):362-4.
The use of intravenous benzodiazepines often results in amnesia for events subsequent to drug administration (anterograde amnesia). To asses the effects of oral administration, a single 2 mg dose of lorazepam was given to 6 normal subjects. No substantial effect on immediate recall of word lists was seen in comparison with 6 placebo control subjects. However, the active drug significantly hindered the delayed recall of words. These findings indicate that lorazepam, taken orally as a daytime tranquilizer, can have amnestic action.
静脉注射苯二氮䓬类药物的使用常常会导致用药后事件的失忆（顺行性失忆）。为评估口服给药的效果，给6名正常受试者单次服用2毫克劳拉西泮。与6名服用安慰剂的对照受试者相比，未观察到对单词表即时回忆有显著影响。然而，活性药物显著阻碍了单词的延迟回忆。这些发现表明，作为日间镇静剂口服的劳拉西泮可产生失忆作用。
