Carless J R, Sheak A
J Pharm Pharmacol. 1976 Jan;28(1):17-22. doi: 10.1111/j.2042-7158.1976.tb04016.x.
Five size fractions of sulphathiazole powder (volume surface mean diameter 155, 133, 86, 50 and 41 mum) were compressed into 12 mm diameter tablets on an instrumented single punch tablet machine. The size analysis of the tablet material after compression showed an attrition of the coarser fraction and an agglomeration of the finer fraction. It is postulated that there is a critical particle size where the effects of crushing and bonding cancel each other. The changes in particle size are discussed in relation to some of the compressive characteristics of the powder.
将五个粒度级分的磺胺噻唑粉末（体积表面平均直径分别为155、133、86、50和41微米）在一台配备仪器的单冲压片机上压制成直径为12毫米的片剂。压制后片剂物料的粒度分析表明，较粗的级分有磨损，较细的级分有团聚。据推测，存在一个临界粒径，在该粒径下破碎和粘结的效果相互抵消。结合粉末的一些压缩特性讨论了粒径的变化。
