Pirofsky B, Ingebo K R, Hefeneider S H
J Biol Response Mod. 1983;2(2):175-85.
A water-soluble, boiled extract produced from the seeds of Ulex europeus (European gorse) was found to inhibit the growth of various reticuloendothelial tumor cell lines. Seven tumor cells, six murine and one human, were investigated and found to be sensitive to the inhibitory activity of such extracts. Ulex seed extracts (USE) reduced the incorporation of tritiated thymidine by tumor cells in an exponential dose - response relationship. In addition, 5- to 8-day cultures of these cell lines grown in the presence of USE had a marked reduction of tumor cell numbers. The reduction in growth exhibited a dose - response relationship. Growth inhibition was not the result of cytotoxicity. Cell viability and washout studies demonstrated the impermanence and easy reversibility of the inhibiting state.
一种从欧洲金雀花种子中提取的水溶性水煮提取物被发现能够抑制多种网状内皮肿瘤细胞系的生长。研究了七种肿瘤细胞，其中六种是鼠源的，一种是人类的，发现它们对此类提取物的抑制活性敏感。欧洲金雀花种子提取物（USE）以指数剂量 - 反应关系降低了肿瘤细胞对氚标记胸腺嘧啶核苷的摄取。此外，在USE存在下培养5至8天的这些细胞系，肿瘤细胞数量显著减少。生长抑制呈现剂量 - 反应关系。生长抑制并非细胞毒性的结果。细胞活力和洗脱研究表明抑制状态是暂时的且易于逆转。
