Wright L L, Cunningham T J, Smolen A J
J Neurocytol. 1983 Oct;12(5):727-38. doi: 10.1007/BF01258147.
Counts of neurons of the rat superior cervical ganglion (SCG) were made at two days before birth and at several postnatal ages. There is a significant decline in the number of apparently normal neurons over the first postnatal week, with the number falling from 39 500 at 3 days to 26 500 at 7 days. Cell numbers then remained constant up to day 60 when the number of neurons was 27 500. The incidence of degenerating neurons, identified by light and electron microscopy, was correlated temporally with the loss of normal neurons. The early manifestations of the neuron degeneration were chromatin clumping and the presence of free monoribosomes. Later stages were characterized by increased chromatin clumping, dense aggregations of monoribosomes, numerous intracytoplasmic vacuoles, and only short segments of rough endoplasmic reticulum. The ultrastructure of the majority of these dying neurons is similar to the 'nuclear' types of degeneration described by Pilar & Landmesser (1976) and Chu-Wang & Oppenheim (1978). Based on the presence of degenerating neurons coincident with the reduction in neuron numbers, we conclude that neuron death is an important aspect of early postnatal development in the rat SCG.
在出生前两天及出生后的几个年龄段，对大鼠颈上神经节（SCG）的神经元进行了计数。在出生后的第一周内，明显正常的神经元数量显著下降，从出生3天时的39500个降至7天时的26500个。然后细胞数量在60天前保持稳定，此时神经元数量为27500个。通过光学显微镜和电子显微镜鉴定的退化神经元的发生率在时间上与正常神经元的减少相关。神经元退化的早期表现为染色质凝聚和游离单核糖体的存在。后期的特征是染色质凝聚增加、单核糖体密集聚集、大量胞质内空泡以及仅短片段的粗面内质网。这些大多数正在死亡的神经元的超微结构类似于皮拉尔和兰德梅塞尔（1976年）以及朱 - 王和奥本海姆（1978年）描述的“核”型退化。基于退化神经元的存在与神经元数量减少同时发生，我们得出结论，神经元死亡是大鼠颈上神经节出生后早期发育的一个重要方面。
