Mbuyi-Muamba J M, Dequeker J
Growth. 1983 Autumn;47(3):301-15.
Collagen and noncollagenous proteins (NCP) have been studied in Wistar rats according to the age and sex. The total amounts of bone matrix proteins, EDTA extracts and the soluble collagenase resistant fraction (SCRF) decreases with aging while the insoluble collagenase resistant fraction (ICRF) increases. No consistent sex-differences have been observed. In the bone matrix, the sialic acid and hexose contents increase with age, the uronic acid value decreases while hydroxyproline does not change. In the EDTA extracts, the collagen extractability decreases markedly with age, the sialic acid content increases while the hexose and uronic acid contents do not vary. Plasma proteins (albumin, orosomucoid and IgG) also do not change with aging. In the collagenase digests, no age and sex differences were found in the collagen and noncollagenous proteins of the SCRF while in the ICRF a decrease was observed for hexoses, uronic acid and sialic acid and an increase for hydroxyproline from the third month onwards.
根据年龄和性别对Wistar大鼠的胶原蛋白和非胶原蛋白（NCP）进行了研究。骨基质蛋白、EDTA提取物和可溶性抗胶原酶部分（SCRF）的总量随衰老而减少，而不溶性抗胶原酶部分（ICRF）则增加。未观察到一致的性别差异。在骨基质中，唾液酸和己糖含量随年龄增加，糖醛酸值降低，而羟脯氨酸不变。在EDTA提取物中，胶原蛋白的可提取性随年龄显著降低，唾液酸含量增加，而己糖和糖醛酸含量不变。血浆蛋白（白蛋白、orosomucoid和IgG）也不随衰老而变化。在胶原酶消化物中，SCRF的胶原蛋白和非胶原蛋白未发现年龄和性别差异，而在ICRF中，从第三个月起己糖、糖醛酸和唾液酸减少，羟脯氨酸增加。
