Voronova L A, Ivanov S D
Vopr Onkol. 1978;24(5):30-5.
During hepatocarcinogenesis, induced in rats with diethylnitrosamine (DENA) and lasting for 6 months, the authors have studied the resistance of hepatic RNA to the degradation by serum RNAs, the resistance being served as a criterion of possible changes in the spacial configuration of polynucleotides. In the precancer period the resistance of RNA molecules (total, cytoplasmic, ribosomal and transfer) is found to considerably increase and then to fall within the range of the studied pH (5.1, 7.6 and 8.5). When the malignancy develops, the RNA resistance to enzymatic cleavage increases again and in most cases exceeds the control level. The comparison of the results obtained with those on the effect of the toxic agent (CCl4) allows a conclusion to be made that the carcinotoxic effect of DENA on the rat liver is accompanied with changes in the spacial configuration of cytoplasmic RNA molecules.
在用二乙基亚硝胺（DENA）诱导大鼠并持续6个月的肝癌发生过程中，作者研究了肝脏RNA对血清RNA降解的抗性，该抗性作为多核苷酸空间构型可能变化的一个标准。在癌前期，发现RNA分子（总RNA、细胞质RNA、核糖体RNA和转移RNA）的抗性显著增加，然后在所研究的pH值范围（5.1、7.6和8.5）内下降。当恶性肿瘤发展时，RNA对酶切的抗性再次增加，并且在大多数情况下超过对照水平。将所得结果与关于毒性剂（CCl4）作用的结果进行比较，可以得出结论，DENA对大鼠肝脏的致癌毒性作用伴随着细胞质RNA分子空间构型的变化。
