Fanger M W, Goldstine S N, Shen L
Mol Immunol. 1983 Sep;20(9):1019-27. doi: 10.1016/0161-5890(83)90043-3.
Receptors for the Fc portion of IgA (RFc alpha) were identified on human monocytes and polymorphonuclear cells (PMNs) by cytofluorograph analysis using FITC-labeled IgA and by rosette formation with IgA-sensitized indicator cells. Larger percentages of PMNs obtained from the oral cavity expressed RFc alpha than did blood PMNs. These oral PMNs also expressed more RFc alpha per cell than blood PMNs. Moreover, the expression of these receptors on blood PMNs was enhanced by overnight incubation with IgA. In functional studies, RFc alpha appeared to cooperate with receptors for IgG in enhancing blood and oral PMN mediated phagocytosis of target cells coated with IgG and IgA. Furthermore, and in contrast with blood PMNs, oral PMNs were capable of phagocytosing target cells coated with IgA alone. Thus, receptors for IgA may be important to the ability of RFc alpha bearing effector cell populations to mediate protection at mucosal surfaces.
通过使用异硫氰酸荧光素（FITC）标记的IgA进行细胞荧光分析以及与IgA致敏指示细胞形成玫瑰花结，在人单核细胞和多形核细胞（PMN）上鉴定出了IgA Fc部分的受体（RFcα）。从口腔获取的PMN中表达RFcα的百分比高于血液中的PMN。这些口腔PMN每个细胞表达的RFcα也比血液PMN多。此外，通过与IgA过夜孵育，血液PMN上这些受体的表达增强。在功能研究中，RFcα似乎与IgG受体协同作用，增强血液和口腔PMN介导的对包被有IgG和IgA的靶细胞的吞噬作用。此外，与血液PMN不同，口腔PMN能够吞噬仅包被有IgA的靶细胞。因此，IgA受体对于携带RFcα的效应细胞群体在黏膜表面介导保护的能力可能很重要。
