Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, United Kingdom.
Departments of Neuroscience and Radiology, 1111 Highland Ave, University of Wisconsin - Madison, Madison, Wisconsin, 53705.
Dev Neurobiol. 2018 Feb;78(2):136-151. doi: 10.1002/dneu.22552. Epub 2017 Nov 10.
Myelin is important for the normal development and healthy function of the nervous system. Recent developments in MRI acquisition and tissue modeling aim to provide a better characterization and more specific markers for myelin. This allows for specific monitoring of myelination longitudinally and noninvasively in the healthy brain as well as assessment of treatment and intervention efficacy. Here, we offer a nontechnical review of MRI techniques developed to specifically monitor myelin such as magnetization transfer (MT) and myelin water imaging (MWI). We further summarize recent studies that employ these methods to measure myelin in relation to development and aging, learning and experience, and neuropathology and psychiatric disorders. © 2017 The Authors. Developmental Neurobiology Published by Wiley Periodicals, Inc. Develop Neurobiol 78: 136-151, 2018.
髓鞘对于神经系统的正常发育和健康功能非常重要。磁共振成像采集和组织建模方面的最新进展旨在为髓鞘提供更好的特征描述和更特异的标志物。这使得髓鞘在健康大脑中的纵向和非侵入性监测以及治疗和干预效果的评估成为可能。在这里，我们提供了一个非技术性的综述，介绍了为专门监测髓鞘而开发的磁共振成像技术，如磁化传递（MT）和髓鞘水成像（MWI）。我们进一步总结了最近的研究，这些研究利用这些方法来测量髓鞘与发育和衰老、学习和经验以及神经病理学和精神疾病的关系。© 2017 作者。发展神经生物学由 Wiley 期刊出版，公司出版。发展神经生物学 78：136-151，2018 年。
