Wolf M E, Keener S, Mathis P, Mosnaim A D
Neuropsychobiology. 1983;9(4):219-22. doi: 10.1159/000117968.
Baclofen therapy resulted in improvement of dyskinesias only in patients with trunkal tardive dyskinesia. However, the appearance of undesirable side effects did not warrant continuation of treatment with this drug. Baclofen did not have any therapeutic effect in schizophrenia and moreover a trend towards a worsening of the psychiatric conditions with irritability, assaultiveness and prominent auditory hallucinations was observed. The effects of baclofen on tardive dyskinesia and schizophrenia can be explained in terms of its phenylethylamine-like properties.
巴氯芬治疗仅使患有躯干迟发性运动障碍的患者的运动障碍得到改善。然而，不良副作用的出现使得继续使用该药物治疗并不合理。巴氯芬对精神分裂症没有任何治疗效果，而且观察到有使精神状况恶化的趋势，表现为易怒、攻击性增强和明显的幻听。巴氯芬对迟发性运动障碍和精神分裂症的作用可以用其苯乙胺样特性来解释。
