Singer P A, Mehler S
Neurosci Lett. 1983 Oct 31;41(1-2):115-8. doi: 10.1016/0304-3940(83)90232-x.
Glucose uptake is increased during motoneuron regeneration. Since this glucose is probably used as an energy source for axonal regeneration we postulated that hypoglycemia might interfere with motoneuron regeneration. In order to partially test this hypothesis we attempted to induce moderate hypoglycemia by fasting rats for 3 days between the time of hypoglossal nerve transection and the time of [14C]2-deoxyglucose (2-DG) and [14C]leucine measurement. We transected one hypoglossal nerve, leaving the other intact, and measured the glucose uptake quantitatively or leucine uptake semiquantitatively in the hypoglossal nucleus. We found that both glucose and leucine uptake were increased in the hypoglossal nuclei during regeneration of the nerve in the fasted animals above that in the normally fed animals. This suggests that fasting creates a deficit of glucose and perhaps leucine which induces increased uptake.
在运动神经元再生过程中，葡萄糖摄取增加。由于这种葡萄糖可能被用作轴突再生的能量来源，我们推测低血糖可能会干扰运动神经元再生。为了部分验证这一假设，我们试图在舌下神经横断至[14C]2-脱氧葡萄糖（2-DG）和[14C]亮氨酸测量期间，通过让大鼠禁食3天来诱导中度低血糖。我们横断一侧舌下神经，另一侧保持完整，并在舌下神经核中定量测量葡萄糖摄取或半定量测量亮氨酸摄取。我们发现，在禁食动物的神经再生过程中，舌下神经核中的葡萄糖和亮氨酸摄取均高于正常喂食动物。这表明禁食造成了葡萄糖甚至可能还有亮氨酸的缺乏，从而诱导摄取增加。
