Das G D, Das K G, Brasko J, Aleman-Gomez J
Neurosci Lett. 1983 Oct 31;41(1-2):73-9. doi: 10.1016/0304-3940(83)90225-2.
Neocortical transplants from 15-, 18- and 22-day rat embryos were transplanted into the cerebellum of the host animals. The necrotic changes and growth in the transplants, the blood in relation to them, and the space containing CSF were analyzed quantitatively in a developmental sequence. The histopathological changes were seen to last for 6-8 days. The neural tissues after initial regression showed recovery, and started to grow in size after 3-4 days. The transplants from 15-day donors showed the highest growth, and this was followed in sequence by those from 18- and 22-day embryos. Techniques involved in manipulation and dissection of the donor embryos, and in transplantation of the tissue, were found to play an important role in the necrotic and other changes in the transplants.
将15日龄、18日龄和22日龄大鼠胚胎的新皮质移植到宿主动物的小脑中。按照发育顺序对移植组织中的坏死变化与生长情况、与之相关的血液以及含有脑脊液的空间进行了定量分析。组织病理学变化持续6 - 8天。神经组织在最初的消退后出现恢复，并在3 - 4天后开始生长。来自15日龄供体的移植组织生长最为显著，其次依次是来自18日龄和22日龄胚胎的移植组织。发现供体胚胎的操作与解剖以及组织移植所涉及的技术在移植组织的坏死及其他变化中起重要作用。
