Campbell G R, Ryan G B
Pathology. 1983 Jul;15(3):253-64. doi: 10.3109/00313028309083503.
The origin of cells comprising the capsule which forms around free-floating intraperitoneal blood clots has been examined in rats. One day after implantation the surface of the clot was covered by 1-2 layers of rounded nucleated cells. The majority of these cells were monocyte/macrophage in type with many cytoplasmic folds. Over the next 2 wk a thick capsule composed of dense connective tissue and myofibroblasts developed, completely covering the clot. The surface became covered by a contiguous layer of mesothelial cells, apparently derived from displaced cells of the damaged peritoneum. Detailed examination of the formation of the capsule suggested that a proportion of cells with the characteristic features of peritoneal macrophages gradually develop over a 3-4 d period the characteristic features of fibroblasts. These cells with time then develop filament bundles and a basal lamina to become myofibroblasts.
在大鼠中，对围绕游离于腹腔内的血凝块形成的包膜所包含细胞的起源进行了研究。植入后一天，血凝块表面覆盖着1 - 2层圆形有核细胞。这些细胞大多数为单核细胞/巨噬细胞类型，有许多细胞质褶皱。在接下来的2周内，由致密结缔组织和成肌纤维细胞组成的厚包膜形成，完全覆盖了血凝块。表面被一层连续的间皮细胞覆盖，这些间皮细胞显然来源于受损腹膜的移位细胞。对包膜形成的详细检查表明，一部分具有腹膜巨噬细胞特征的细胞在3 - 4天的时间里逐渐发展出成纤维细胞的特征。随着时间的推移，这些细胞形成细丝束和基膜，成为成肌纤维细胞。
