驯化异物反应：最新进展与应用。
Domesticating the foreign body response: Recent advances and applications.
机构信息
Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77030, USA.
Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, USA.
出版信息
Adv Drug Deliv Rev. 2019 Apr;144:148-161. doi: 10.1016/j.addr.2019.08.010. Epub 2019 Sep 3.
Abstract
The foreign body response is an immunological process that leads to the rejection of implanted devices and presents a fundamental challenge to their performance, durability, and therapeutic utility. Recent advances in materials development and device design are now providing strategies to overcome this immune-mediated reaction. Here, we briefly review our current mechanistic understanding of the foreign body response and highlight new anti-FBR technologies from this decade that have been applied successfully in biomedical applications relevant to implants, devices, and cell-based therapies. Further development of these important technologies promises to enable new therapies, diagnostics, and revolutionize the management of patient care for many intractable diseases.
摘要
异物反应是一种免疫过程，导致植入设备的排斥，并对其性能、耐久性和治疗效果构成根本挑战。最近在材料开发和设备设计方面的进展，为克服这种免疫介导的反应提供了策略。在这里，我们简要回顾了我们目前对异物反应的机制理解，并强调了过去十年中应用于与植入物、设备和基于细胞的治疗相关的生物医学应用的新型抗 FBR 技术。这些重要技术的进一步发展有望实现新的治疗方法、诊断方法，并彻底改变许多难治性疾病的患者管理。
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