巴尔干（地方性）肾病与疣孢青霉变种产毒素菌株：大鼠实验模型
Balkan (endemic) nephropathy and a toxin-producing strain of Penicillium verrucosum var cyclopium: An experimental model in rats.
作者信息
Barnes J M, Austwick P K, Carter R L, Flynn F V, Peristianis G C, Aldridge W N
出版信息
Lancet. 1977 Mar 26;1(8013):671-5. doi: 10.1016/s0140-6736(77)92115-8.
Abstract
Cultures of an isolate of Penicillium verrucosum var. cyclopium, obtained from stored maize in an area of Balkan (endemic) nephropathy--Vratza, Bulgaria--has consistently induced renal tubular lesions when force-fed to rats for 20 days. The lesions, confined to the lower reaches of the proximal convoluted tublues (pars recta and junctional zone), closely resemble the tubular changes in patients with Balkan nephropathy. Preliminary evidence suggests that this nephrotoxin-producing strain of P. verrucosum var. cyclopium may be implicated in the aetiology of Balkan nephropathy.
摘要
从保加利亚弗拉察（巴尔干肾病的地方性流行区）储存的玉米中分离出的疣孢青霉变种环孢菌，在强制喂养大鼠20天后，一直会诱发肾小管病变。这些病变局限于近端曲管的下游部分（直部和连接区），与巴尔干肾病患者的肾小管变化极为相似。初步证据表明，这种产生肾毒素的疣孢青霉变种环孢菌菌株可能与巴尔干肾病的病因有关。
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