地方性（巴尔干）肾病的病毒病因学证据。
Evidence of a viral aetiology in endemic (Balkan) nephropathy.
作者信息
Apostolov K, Spasic P
出版信息
Lancet. 1975 Dec 27;2(7948):1271-3. doi: 10.1016/s0140-6736(75)90609-1.
Segemental and focal pathological changes were found in the glomeruli and tubules of postoperative renal-biopsy specimens from seven cases of clinically confirmed endemic (Balkan) nephropathy. In the glomeruli, there was mesangial reaction and segmental thickening of the basement membrane with subendothelial and membranous depositions. In the tubules there was spongiform degeneration and fusion of cells. In all the cells of the nephron numerous cytoplasmic vesicles containing free and budding particles (80-200 nm) were found. These particles had the characteristics of a coronarivus. Balkan nephropathy occurs almost exclusively in people who have been in close contact with pigs. Coronaviruses have been isolated from pigs, and it is suggested that a slow coronavirus infection causes endemic nephropathy in man.
在7例临床确诊的地方性（巴尔干）肾病患者术后肾活检标本的肾小球和肾小管中发现了节段性和局灶性病理变化。在肾小球中，有系膜反应和基底膜节段性增厚，伴有内皮下和膜性沉积物。在肾小管中有海绵状变性和细胞融合。在肾单位的所有细胞中都发现了许多含有游离和出芽颗粒（80-200纳米）的细胞质小泡。这些颗粒具有冠状病毒的特征。巴尔干肾病几乎只发生在与猪密切接触的人群中。冠状病毒已从猪身上分离出来，有人认为慢冠状病毒感染会导致人类地方性肾病。
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