Snapir N, Robinzon B, Shalita B
Pharmacol Biochem Behav. 1983 Oct;19(4):617-24. doi: 10.1016/0091-3057(83)90337-4.
The effects of long-term injections of testosterone propionate (TP), diethylstilbestrol (DES) and TP+DES simultaneously to castrated and sham-operated White Leghorn cocks on feeding, weight gain, obesity, blood lipids and weight of various glands were studied. DES induced marked adiposity while TP reduced carcass fat content. Injections of TP+DES induced only moderate obesity. The responses of the castrated cocks to TP or DES were not always parallel to those of the sham-operated ones. In sham-operated cocks, TP induced permanent hypophagia and emaciation while in castrated cocks, although alleviating adiposity, it did not reduce the rate of weight gain and induced only a transient hypophagia. DES induced permanent hyperphagia and accelerated weight gain in sham-operated cocks while in those castrated, it induced only transient hyperphagia which later on changed into hypophagia. Although the latter cocks did not gain more weight than those castrated with no steroids supplementation, they were much more obese and had a fat content similar to that of the sham-operated ones treated with DES. The castration was found to alleviate the depressing effect of TP on adenohypophyseal and thyroidal weights. The results may suggest: (1) In the White Leghorn cocks, DES increases lipogenesis and food intake while TP results in the contrary. (2) Castration should not be considered as a lack of gonadal steroids only.
研究了长期向去势和假手术的白来航公鸡注射丙酸睾酮（TP）、己烯雌酚（DES）以及同时注射TP+DES对其摄食、体重增加、肥胖、血脂和各种腺体重量的影响。DES可导致明显肥胖，而TP可降低胴体脂肪含量。注射TP+DES仅引起中度肥胖。去势公鸡对TP或DES的反应并不总是与假手术公鸡的反应平行。在假手术公鸡中，TP可导致永久性摄食减少和消瘦，而在去势公鸡中，尽管减轻了肥胖，但并未降低体重增加速率，仅引起短暂性摄食减少。DES可导致假手术公鸡永久性摄食亢进和体重加速增加，而在去势公鸡中，它仅引起短暂性摄食亢进，随后转变为摄食减少。尽管后一组公鸡的体重增加并不比未补充类固醇的去势公鸡多，但它们肥胖得多，脂肪含量与用DES处理的假手术公鸡相似。发现去势可减轻TP对腺垂体和甲状腺重量的抑制作用。结果可能提示：（1）在白来航公鸡中，DES增加脂肪生成和食物摄入量，而TP则相反。（2）去势不应仅被视为缺乏性腺类固醇。
