Gentry R T, Wade G N
J Comp Physiol Psychol. 1976 Jan;90(1):18-25. doi: 10.1037/h0077264.
Castration of adult male rats produces a delayed (by approximately 1 mo), permanent hypophagia and reduction in weight gain. This contrasts with the rapid, transient hyperphagia and increased weight gain caused by ovariectomy in female rats. Injections of testosterone propionate (TP) stimulate food intake and weight gain in castrated males. Neither 5alpha-reduction nor aromatization of the testosterone molecule plays an important role in the stimulation of these measures by TP. The 5alpha-reduced metabolite of TP, 5alpha-dihydrotestosterone propionate (DHTP), is less effective in increasing eating and weight gain than is TP. Very high doses of TP may actually reduce weight gain with prolonged treatment (2-6 wk). It is likely that this reduced weight gain is due to aromatization of TP to an estrogen. The nonaromatizable androgen, DHTP, does not reduce weight gain even in very high doses, and concurrent progesterone injections reverse the weight-reducing actions of high TP doses.
成年雄性大鼠去势会导致延迟（约1个月）的永久性食欲减退和体重增加减少。这与雌性大鼠卵巢切除后迅速出现的短暂性食欲亢进和体重增加增加形成对比。注射丙酸睾酮（TP）可刺激去势雄性大鼠的食物摄入量和体重增加。睾酮分子的5α-还原或芳香化在TP对这些指标的刺激中均不起重要作用。TP的5α-还原代谢产物丙酸5α-双氢睾酮（DHTP）在增加进食和体重增加方面比TP效果差。非常高剂量的TP在长期治疗（2至6周）时实际上可能会减少体重增加。这种体重增加减少可能是由于TP芳香化为雌激素所致。不可芳香化的雄激素DHTP即使在非常高的剂量下也不会减少体重增加，同时注射孕酮可逆转高剂量TP的体重减轻作用。
