Grodzińska L, Panczenko B, Gryglewski R J
J Pharm Pharmacol. 1976 Jan;28(1):40-3. doi: 10.1111/j.2042-7158.1976.tb04020.x.
Infusions of noradrenaline (1-3 mug ml(-1) min(-1)) into the mesenteric vascular preparation of the rabbit caused a 2 to 5 fold rise in perfusion pressure and a release of prostaglandin E-like material (3.23 +/- 0.65 (s.e.) ng PGE2 equivalents ml(-1)). Indomethacin (3 mug ml(-1)) prevented whereas arachidonic acid (0.2 mug ml(-1)) augmented, the noradrenaline-evoked release of a prostaglandin E-like material. The walls of arterioles or precapillary vessels are the proposed site of prostaglandin generation.
向兔肠系膜血管制备物中输注去甲肾上腺素（1 - 3微克/毫升(-1) 分钟(-1)）可使灌注压升高2至5倍，并释放出前列腺素E样物质（3.23 +/- 0.65（标准误）纳克PGE2当量/毫升(-1)）。吲哚美辛（3微克/毫升(-1)）可抑制，而花生四烯酸（0.2微克/毫升(-1)）可增强去甲肾上腺素诱发的前列腺素E样物质的释放。小动脉或毛细血管前血管壁被认为是前列腺素生成的部位。
